UMass Amherst

John Nambu

Biology

Ph.D., Stanford University


Most people see fruit flies as merely a nuisance, but to Biology Professor John Nambu they are fascinating. He uses common Drosophila fruit flies as a model system for his research on the genetics of organismal development. In particular, his laboratory studies the mechanisms of gene regulation and programmed cell death. These fundamental processes are critical for the normal formation of organs and tissues in all developing animals.

Professor Nambu typically has several undergraduates who work alongside graduate students in his laboratory. He enjoys the energy and enthusiasm that undergraduates bring to the lab and is constantly impressed by their talent and commitment. "Many students make significant contributions to our research program, and some are ultimately co-authors on research papers," Nambu says. "The students also see firsthand what it's like to go to graduate school," he explains. "I think that they're able to make a more informed decision about a career choice."

Unlike labs for classes in which experiments are designed with known outcomes, Nambu comments that "with research, there is no guarantee as to how it's going to turn out. Overall, it is a very demanding endeavor." Professor Nambu savors the moment when students realize the results of their experiments may be of real importance or interest. "All of a sudden, they just light up."

To Professor Nambu working together in a lab has a camaraderie a lot like being on a sports team. "We come from different backgrounds and work closely together toward a related goal. When something works, everyone gets to share in that."